Representative Publications

Crystal structures of MHC class I complexes reveal the elusive intermediate conformations explored during peptide editing

​Li, L., Peng, X., Batliwala, M., and Bouvier, M. (2023) Nat. Commun. 14: 5020.

UIC Today News Release

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SARS-CoV-2 ORF8: One protein, seemingly one structure, and many functions

Vinjamuri, S., Li, L., and Bouvier, M. (2022) Front. Immunol. 13: 1035559.

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Discovery of the first selective nonamolar inhibitors of ERAP2 by kinetics-target guided synthesis

Camberlein, V., Fleau, C., Sierocki, P., Li, L., Gealageas, R., …, Bouvier, M., and Deprez-Poulain, R. (2022) Angew. Chem. 61: e202203560

UIC News Release

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Intracellular Sequestration of the NKG2D Ligand MIC B by Species F Adenovirus

Edson R.A. Oliveira, Lenong Li, and Marlene Bouvier (2021) Viruses 13: 1289

 

ERAP1 enzyme-mediated trimming and structural analyses of MHC-1 bound precursor peptides yield novel insights into antigen processing and presentation

Li, L., Batliwala, M., and Bouvier, M. (2019) J. Biol. Chem. 294: 18523-18544.

JBC Editors' Pick; Cover Figure; Featured; UIC News Release

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Immune evasion by Adenoviruses: a window into host-virus adaptation

Oliveira, E. and Bouvier, M. (2019) FEBS Lett. 593: 3496-3503.

Special issue on Adenoviruses

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In Vitro Studies of MHC Class I Peptide Loading and Exchange

Bouvier, M. (2019) Antigen Processing: Methods and Protocols, Methods in Molecular Biology (P. van Endert, Ed.), 1988: 71-81. 

 

Trimming of MHC Class I Ligands by ERAP Aminopeptidases

Weimershaus, M.,  Evnouchidou, I.,  Li, L., van Endert, P., and Bouvier, M. (2019) Antigen Processing: Methods and Protocols, Methods in Molecular Biology (P. van Endert, Ed.), 1988: 31-43. 

 

Discovery of small molecule inhibitors of adenovirus by disrupting E3-19K/HLA-A2 interactions

Ren, J., Dsouza, N. R., Deng, H., Lee, H., Bouvier, M., and Johnson, M. E. (2018) Bioorg. Med. Chem. Lett. 28: 2837-2841. 

 

ERAP1-ERAP2 dimers trim MHC I-bound precursor peptides; implications for understanding peptide editing

Chen, H., Li, L., Weimershaus, M., Evnouchidou, I., van Endert, P., and Bouvier, M. (2016) Sc. Rep. 6: 28902. 

Faculty1000Prime Recommendation 

 

Structure of the adenovirus type 4 (species E) E3-19K/HLA-A2 complex reveals species-specific features in MHC I

Li, L., Santarsiero, B. D., and Bouvier, M. (2016) J. Immunol. 197: 1399-1407.

 

Studying MHC class I peptide loading and exchange in vitro

Bouvier M. (2013) Antigen Processing: Methods and Protocols, Methods in Molecular Biology (P. van Endert, Ed.), 960: 81-91. 

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Crystal structure of adenovirus E3-19K protein bound to HLA-A2 reveals mechanism for immunomodulation

Li, L, Muzahim, Y, and Bouvier M. (2012) Nat. Struct. Mol. Biol. 19: 1176-1181. 

 

Determinants of the endoplasmic reticulum (ER) lumenal-domain of the adenovirus serotype 2 E3-19K protein for association with and ER-retention of major histocompatibility complex class I molecules

Fu, J. and Bouvier, M. (2011) Molec. Immunol. 48: 532-538. 

 

Adenovirus E3-19K proteins of different serotypes and subgroups have similar, yet distinct, immunomodulatory functions toward major histocompatibility class I molecules

Fu, J., Li, L., and Bouvier, M. (2011) J. Biol. Chem. 286: 17631-17639. 

 

MHC class I antigen presentation: Learning from viral evasion strategies

Bouvier, M. and Hansen, T. H. (2009) Nat. Rev. Immunol. 9: 503-513. 

 

The convergent roles of tapasin and HLA-DM in antigen presentation

Sadegh-Nasseri, S., Chen, M., Narayan, K., and Marlene, B. (2008) Trends Immunol. 29: 141-147. 

 

Analysis of interactions in a tapasin/class I complex provides a mechanism for peptide selection

Chen, M. and Bouvier, M. (2007)The EMBO J. 26: 1681-1690. 

Faculty1000Prime Recommendation 

 

Allele- and locus-specific recognition of class I MHC molecules by the immunomodulatory E3-19K protein from adenovirus

Chen, M. and Bouvier, M. (2007) J. Immunol. 178: 4567-4575. 

 

The calcium- and zinc-responsive regions of calreticulin reside strictly in the N-/C-domain

Tan, Y., Chen, M., Li, Z., Mabuchi, K., and Bouvier, M. (2006) BBA - General Subjects 1760: 745-753. 

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The endoplasmic reticulum lumenal domain of the adenovirus type 2 E3-19K protein binds to peptide-filled and peptide-deficient HLA-A1101 molecules

Tan, Y., Chen, M., Li, Z., Mabuchi, K., and Bouvier, M. (2006) J. Virol. 79: 13317-13325. 

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Biochemical and structural impact of natural polymorphism in the HLA-A3 superfamily

Li, L. and Bouvier, M. (2005) Molec. Immunol. 42: 1331-1344. 

 

A biochemical and structural analysis of genetic diversity within the HLA-A11 subtype

Li, L., Chen, W., and Bouvier, M. (2005) Immunogenetics 57: 315-325. 

 

ERp57 is a multifunctional thiol-disulfide oxidoreductase

Frickel, Patrick Frei, P., Bouvier, M, Stafford, W.F., Helenius, A., Glockshuber, R., and Ellgaard, L. (2004)

J. Biol. Chem. 279: 18277-18287. 

 

Structures of HLA-A1101 complexed with immunodominant nonamer and decamer HIV-1 epitopes clearly reveal the presence of a middle, secondary anchor residue

Li, L. and Bouvier, M. (2004) J. Immunol. 172: 6175-6184. 

 

Accessory proteins and the assembly of human class I MHC molecules: A molecular and structural perspective

Bouvier, M. (2003) Molec. Immunol. 39: 697-706.

 

A characterization of the lumenal region of human tapasin reveals the presence of two structural domains.

Chen, M., Stafford, W. F., Diedrich, G., Khan, A., and Bouvier, M. (2002) Biochem. 41: 14539-14545. 

 

Crystallization and preliminary x‐ray crystallographic studies of HLA‐A1101 complexed with an HIV‐1 decapeptide.

Li, L., Promadej, N., McNicholl, J. M., and Bouvier, M. (2002)  Acta Crystal. Sec. D 58: 195-197. 

 

The metal ion binding properties of calreticulin modulate its conformational flexibility and thermal stability.

Li, Z., Stafford W.F., and Bouvier, M. (2001) Biochem. 40: 11193-12201.