Representative Publications

Longitudinal analysis of the gut microbiota during anti-PD-1 therapy reveals stable microbial features of response in melanoma patients

Macandog, A. D. G., Catozzi, C., ..., Bouvier, M., Andrews, M. C., Xiaowei, X., Santambrogio, L., Segata, N., Buonaguro, L., Cocorocchio, E., Ascierto, P. A., Manzo, T., and Nezi, L. (2024) Cell Host Microbe. 32: 2004-2018.

​

Crystal structures of MHC class I complexes reveal the elusive intermediate conformations explored during peptide editing

​Li, L., Peng, X., Batliwala, M., and Bouvier, M. (2023) Nat. Commun. 14: 5020.

UIC Today News Release

​

SARS-CoV-2 ORF8: One protein, seemingly one structure, and many functions

Vinjamuri, S., Li, L., and Bouvier, M. (2022) Front. Immunol. 13: 1035559.

​

Discovery of the first selective nonamolar inhibitors of ERAP2 by kinetics-target guided synthesis

Camberlein, V., Fleau, C., Sierocki, P., Li, L., Gealageas, R., …, Bouvier, M., and Deprez-Poulain, R. (2022) Angew. Chem. 61: e202203560

UIC News Release

​

Intracellular Sequestration of the NKG2D Ligand MIC B by Species F Adenovirus

Edson R.A. Oliveira, Lenong Li, and Marlene Bouvier (2021) Viruses 13: 1289

 

ERAP1 enzyme-mediated trimming and structural analyses of MHC-1 bound precursor peptides yield novel insights into antigen processing and presentation

Li, L., Batliwala, M., and Bouvier, M. (2019) J. Biol. Chem. 294: 18523-18544.

JBC Editors' Pick; Cover Figure; Featured; UIC News Release

​

Immune evasion by Adenoviruses: a window into host-virus adaptation

Oliveira, E. and Bouvier, M. (2019) FEBS Lett. 593: 3496-3503.

Special issue on Adenoviruses

​

In Vitro Studies of MHC Class I Peptide Loading and Exchange

Bouvier, M. (2019) Antigen Processing: Methods and Protocols, Methods in Molecular Biology (P. van Endert, Ed.), 1988: 71-81. 

 

Trimming of MHC Class I Ligands by ERAP Aminopeptidases

Weimershaus, M.,  Evnouchidou, I.,  Li, L., van Endert, P., and Bouvier, M. (2019) Antigen Processing: Methods and Protocols, Methods in Molecular Biology (P. van Endert, Ed.), 1988: 31-43. 

 

Discovery of small molecule inhibitors of adenovirus by disrupting E3-19K/HLA-A2 interactions

Ren, J., Dsouza, N. R., Deng, H., Lee, H., Bouvier, M., and Johnson, M. E. (2018) Bioorg. Med. Chem. Lett. 28: 2837-2841. 

 

ERAP1-ERAP2 dimers trim MHC I-bound precursor peptides; implications for understanding peptide editing

Chen, H., Li, L., Weimershaus, M., Evnouchidou, I., van Endert, P., and Bouvier, M. (2016) Sc. Rep. 6: 28902. 

Faculty1000Prime Recommendation 

 

Structure of the adenovirus type 4 (species E) E3-19K/HLA-A2 complex reveals species-specific features in MHC I

Li, L., Santarsiero, B. D., and Bouvier, M. (2016) J. Immunol. 197: 1399-1407.

 

Studying MHC class I peptide loading and exchange in vitro

Bouvier M. (2013) Antigen Processing: Methods and Protocols, Methods in Molecular Biology (P. van Endert, Ed.), 960: 81-91. 

​

Crystal structure of adenovirus E3-19K protein bound to HLA-A2 reveals mechanism for immunomodulation

Li, L, Muzahim, Y, and Bouvier M. (2012) Nat. Struct. Mol. Biol. 19: 1176-1181. 

 

Determinants of the endoplasmic reticulum (ER) lumenal-domain of the adenovirus serotype 2 E3-19K protein for association with and ER-retention of major histocompatibility complex class I molecules

Fu, J. and Bouvier, M. (2011) Molec. Immunol. 48: 532-538. 

 

Adenovirus E3-19K proteins of different serotypes and subgroups have similar, yet distinct, immunomodulatory functions toward major histocompatibility class I molecules

Fu, J., Li, L., and Bouvier, M. (2011) J. Biol. Chem. 286: 17631-17639. 

 

MHC class I antigen presentation: Learning from viral evasion strategies

Bouvier, M. and Hansen, T. H. (2009) Nat. Rev. Immunol. 9: 503-513. 

 

The convergent roles of tapasin and HLA-DM in antigen presentation

Sadegh-Nasseri, S., Chen, M., Narayan, K., and Marlene, B. (2008) Trends Immunol. 29: 141-147. 

 

Analysis of interactions in a tapasin/class I complex provides a mechanism for peptide selection

Chen, M. and Bouvier, M. (2007)The EMBO J. 26: 1681-1690. 

Faculty1000Prime Recommendation 

 

Allele- and locus-specific recognition of class I MHC molecules by the immunomodulatory E3-19K protein from adenovirus

Chen, M. and Bouvier, M. (2007) J. Immunol. 178: 4567-4575. 

 

The calcium- and zinc-responsive regions of calreticulin reside strictly in the N-/C-domain

Tan, Y., Chen, M., Li, Z., Mabuchi, K., and Bouvier, M. (2006) BBA - General Subjects 1760: 745-753. 

​

The endoplasmic reticulum lumenal domain of the adenovirus type 2 E3-19K protein binds to peptide-filled and peptide-deficient HLA-A1101 molecules

Tan, Y., Chen, M., Li, Z., Mabuchi, K., and Bouvier, M. (2006) J. Virol. 79: 13317-13325. 

​

Biochemical and structural impact of natural polymorphism in the HLA-A3 superfamily

Li, L. and Bouvier, M. (2005) Molec. Immunol. 42: 1331-1344. 

 

A biochemical and structural analysis of genetic diversity within the HLA-A11 subtype

Li, L., Chen, W., and Bouvier, M. (2005) Immunogenetics 57: 315-325. 

 

ERp57 is a multifunctional thiol-disulfide oxidoreductase

Frickel, Patrick Frei, P., Bouvier, M, Stafford, W.F., Helenius, A., Glockshuber, R., and Ellgaard, L. (2004)

J. Biol. Chem. 279: 18277-18287. 

 

Structures of HLA-A1101 complexed with immunodominant nonamer and decamer HIV-1 epitopes clearly reveal the presence of a middle, secondary anchor residue

Li, L. and Bouvier, M. (2004) J. Immunol. 172: 6175-6184. 

 

Accessory proteins and the assembly of human class I MHC molecules: A molecular and structural perspective

Bouvier, M. (2003) Molec. Immunol. 39: 697-706.

 

A characterization of the lumenal region of human tapasin reveals the presence of two structural domains.

Chen, M., Stafford, W. F., Diedrich, G., Khan, A., and Bouvier, M. (2002) Biochem. 41: 14539-14545. 

 

Crystallization and preliminary x‐ray crystallographic studies of HLA‐A1101 complexed with an HIV‐1 decapeptide.

Li, L., Promadej, N., McNicholl, J. M., and Bouvier, M. (2002)  Acta Crystal. Sec. D 58: 195-197. 

 

The metal ion binding properties of calreticulin modulate its conformational flexibility and thermal stability.

Li, Z., Stafford W.F., and Bouvier, M. (2001) Biochem. 40: 11193-12201.